| 多肽名称 | [Pyr3]-beta-Amyloid (3-40), Human |
| 纯度 | HPLC ≥ 95% |
| 描述 | This peptide triggers the formation of insoluble Aß peptide deposits, inhibits secretion of amyloid protein precursor (APP) and increases cell-associated APP. The fibrils in the plaques formed in the brains of patients with Alzheimer’s disease contain significant amounts of truncated Aß proteins such as Aß(3-40) and Aß (11- 40). These two fragments contain an N-terminal pyroglutamic acid. The g-carboxy group of glutamic acid forms a cyclic bond with the free N-terminal amino group to form pyroglutamate. |
| 存储 | -20°C |
| 参考论文 | Mok, SS. et al. J. Neurosci. Res. 61, 449 (2000); Russo, C. et al. Nature. 405, 531 (2000). |
| 分子量 | 4125.7 |
| 多肽序列（单字母） | Pyr-FRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV |
| 多肽序列（三字母） | Pyr - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - His - His - Gln - Lys - Leu - Val - Phe - Phe - Ala - Glu - Val - Gly - Asp - Ser - Asn - Lys - Gly - Ala - Ile - Ile - Gly - Leu - Met - Val - Gly - Gly - Val - Val - OH |
[Pyr3]-beta-Amyloid (3-40), Human
Elisa Q.
2020-11-04T19:00:08+08:00
