多肽名称 | (Val³⁴)-Amyloid β-Protein (1-40) |
纯度 | HPLC ≥ 95% |
描述 | Cerebral amyloid angiopathy (CAA) is a common finding in Alzheimer’s disease in which amyloid-Aβ vascular deposits are featured in >80% of the cases. Mutations in the positions 21-23 (e.g. Dutch mutation E22Q) are primarily associated with CAA, although they manifest with strikingly different clinical phenotypes: cerebral hemorrhage or dementia. The Piedmont L34V Aβ mutant, located outside this hot spot, shows a similar hemorrhagic phenotype, albeit less aggressive than the widely studied Dutch variant. |
存储 | -20°C |
参考论文 | S.Fossati et al., FASEB J., 24, 229 (2010) L.Obici et al., Ann. Neurol., 58, 639 (2005) |
分子量 | 4315.84 |
多肽序列(单字母) | DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGVMVGGVV |
多肽序列(三字母) | H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Val-Met-Val-Gly-Gly-Val-Val-OH |
(Val³⁴)-Amyloid β-Protein (1-40)
Elisa Q.
2020-11-04T18:00:23+08:00