Cyproheptadine hydrochloride
Cyproheptadine hydrochloride 是 5-HT2 受体拮抗剂，IC50为0.6 nM。
中文名：盐酸赛庚啶
英文名：Cyproheptadine hydrochloride
CAS 号： 969-33-5
分子式：C₂₁H₂₂ClN
分子量：323.86
纯度：>98.0%
| Description | Cyproheptadine hydrochloride is a histamine receptor antagonist for 5-HT2 receptor with IC50 of 0.6 nM. Target: 5-HT2 Receptor Cyproheptadine hydrochloride is a serotonin antagonist and a histamine H2 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc. Inhibitory effects of Cyproheptadine (hydrochloride), amitriptyline, and cyproheptadine on mono- and polysynaptic reflex potentials are due to the inhibition of descending serotonergic systems through 5-HT(2) receptors in the spinal cord [1, 2]. |
| Target | 5-HT2 Receptor |
| References | [1]. Honda, M., T. Nishida, and H. Ono, Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors. Eur J Pharmacol, 2003. 458(1-2): p. 91-9. [2]. Calka, O., et al., Effect of cyproheptadine on serum leptin levels. Adv Ther, 2005. 22(5): p. 424-8. |
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