Idalopirdine
Idalopirdine (Lu AE58054) 是有效，选择性的 5-HT6 受体拮抗剂，Ki 为 0.83 nM。
中文名：N-[2-(6-氟-1H-吲哚-3-基)乙基]-3-(2,2,3,3-四氟丙氧基)苄胺
英文名：Lu AE58054; Idalopirdine
CAS 号： 467459-31-0
分子式：C20H19F5N2O
分子量：398.370
纯度：>98.0%
| Description | Idalopirdine (Lu AE58054) is a potent and selective 5-HT6 receptor antagonist with a Ki of 0.83 nM. |
| Target | 5-HT6 Receptor |
| References | [1]. Arnt J, Bang-Andersen B, Grayson B, Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats. Int J Neuropsychopharmacol. 2010 Sep;13(8):1021-33. [2]. Witten L, Bang-Andersen B, Nielsen SM, Characterization of [?H]Lu AE60157 ([?H]8-(4-methylpiperazin-1-yl)-3-phenylsulfonylquinoline) binding to 5-hydroxytryptamine? (5-HT?) receptors in vivo.Eur J Pharmacol. 2012 Feb 15;676(1-3):6-11. |
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