Rupatadine
Rupatadine(UR-12592)是PAF/H1受体双效抑制剂，Ki值分别为0.55uM和0.1uM。
中文名：芦帕他定
英文名：Rupatadine
CAS 号： 158876-82-5
分子式：C26H26ClN3
分子量：415.958
纯度：>98.0%
| 描述 | Rupatadine(UR-12592)是PAF/H1受体双效抑制剂，Ki值分别为0.55uM和0.1uM。 |
| 靶点 | 5-HT受体 |
| 参考文献 | [1]. Merlos M, et al. Rupatadine, a new potent, orally active dual antagonist of histamine and platelet-activating factor (PAF). J Pharmacol Exp Ther. 1997 Jan;280(1):114-21. [2]. Queralt M, et al. In vitro inhibitory effect of rupatadine on histamine and TNF-alpha release from dispersed canine skin mast cells and the human mast cell line HMC-1. Inflamm Res. 2000 Jul;49(7):355-60. [3]. Lv XX, et al. Rupatadine protects against pulmonary fibrosis by attenuating PAF-mediated senescence in rodents. PLoS One. 2013 Jul 15;8(7):e68631 |
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