Setiptiline maleate
Setiptiline是5-HT受体拮抗剂。
中文名：马来酸司普替林
英文名：Setiptiline maleate; MO-8282
CAS 号： 85650-57-3
分子式：C₂₃H₂₃NO₄
分子量：377.43
纯度：>98.0%
| Description | Setiptiline is a serotonin receptor antagonist. IC50 value: Target: 5-HT receptor Setiptiline is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA). Setiptiline acts as a norepinephrine reuptake inhibitor, α2-adrenergic receptor antagonist, and serotonin receptor antagonist, likely at the 5-HT2A, 5-HT2C, and/or 5-HT3 subtypes, as well as an H1 receptor inverse agonist/antihistamine. From Wikipedia. |
| Target | 5-HT |
| References | [1]. Niho T, et al. [Pharmacological properties of MO-8282, a novel antidepressant]. Nihon Yakurigaku Zasshi. 1986 Oct;88(4):309-20. [2]. Setiptiline [3]. Yamada K, et al. [Behavioral effects of a new antidepressant, setiptiline]. Nihon Yakurigaku Zasshi. 1991 Jan;97(1):31-9. [4]. Kamimura M, et al. The effect of age on plasma level of setiptiline maleate in depressed patients. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Oct;18(6):1015-26. [5]. Kuniyoshi M, et al. Effectiveness of concomitant setiptiline maleate (Tecipul) on negative symptoms of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Mar;18(2):339-46. |
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