Vilazodone
Vilazodone(EMD 68843; SB 659746A)是五羟色胺重吸收抑制剂（SSRI）和5-HT1A受体部分激动剂。
中文名：维拉佐酮
英文名：Vilazodone;EMD 68843; SB659746A
CAS 号： 163521-12-8
分子式：C26H27N5O2
分子量：441.52
纯度：>98.0%
| Description | Vilazodone (EMD 68843; SB 659746A) is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist currently under clinical evaluation for the treatment of major depression. IC50 value: Target: SSRI; 5-HT1A Vilazodone represents another option for the treatment of MDD. Vilazodone appears to have a favourable weight-gain profile based on short-term studies. Sexual side-effects were not consistently demonstrated when assessed using clinical rating scales but spontaneously reported AEs related to sexual functioning were observed. Additional controlled data regarding long-term efficacy and effectiveness will help characterise this new agent when used in maintenance treatment. |
| Target | 5-HT1A Receptor |
| References | Vilazodone: a novel antidepressant. Choi E, et al. Am J Health Syst Pharm. 2012 Sep 15;69(18):1551-7. PMID: 22935937. |
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